Very interesting thought.
JUST SOME THOUGHTS:
URE (United Republic of Earth) to me says that THEY went to the moon or space at some point. If not , why have the word Earth in it?
The Federation is Earth bound.
The lunar biome is not Earth's as the Dev said it orbits another planet.
Watch the trailer again as Helena intereacts with HLN-A and then fades away.
Then watch HLN-A interact with REALITY?
Why is the Genesis Sim a cylinder like the trailer shows?
What void are we sat in in that trailer?
I think your view Hippo is very good. The fighting could have gone beyond Earth after Santiago's time.