Possibly, one player would need to use an X-Box controller for the PC. If ever implement for PC, there is also the capability for gaming computers using high end graphic card to run dual monitors. Of course, the game would have to capable of supporting a dual monitor setup as opposed to the split screen. 1080P display should also have the option of being split vertically.
Currently, one can use the Host/Local and set up two or more computers connected via the network for a multiplayer party.